abstract：:Coronavirus disease 2019 (COVID-19) is a novel respiratory illness caused by SARS-CoV-2. Viral entry is mediated through viral spike protein and host ACE2 enzyme interaction. Most cases are mild; severe disease often involves cytokine storm and organ failure. Therapeutics including antivirals, immunomodulators, and va...

journal_title：Cell

authors： Oberfeld B,Achanta A,Carpenter K,Chen P,Gilette NM,Langat P,Said JT,Schiff AE,Zhou AS,Barczak AK,Pillai S

更新日期：2020-05-14 00:00:00

abstract：:Conversion of glial cells into functional neurons represents a potential therapeutic approach for replenishing neuronal loss associated with neurodegenerative diseases and brain injury. Previous attempts in this area using expression of transcription factors were hindered by the low conversion efficiency and failure o...

journal_title：Cell

authors： Zhou H,Su J,Hu X,Zhou C,Li H,Chen Z,Xiao Q,Wang B,Wu W,Sun Y,Zhou Y,Tang C,Liu F,Wang L,Feng C,Liu M,Li S,Zhang Y,Xu H,Yao H,Shi L,Yang H

更新日期：2020-04-30 00:00:00

abstract：:Liquid-liquid phase separation (LLPS) mediates formation of membraneless condensates such as those associated with RNA processing, but the rules that dictate their assembly, substructure, and coexistence with other liquid-like compartments remain elusive. Here, we address the biophysical mechanism of this multiphase o...

journal_title：Cell

authors： Sanders DW,Kedersha N,Lee DSW,Strom AR,Drake V,Riback JA,Bracha D,Eeftens JM,Iwanicki A,Wang A,Wei MT,Whitney G,Lyons SM,Anderson P,Jacobs WM,Ivanov P,Brangwynne CP

更新日期：2020-04-16 00:00:00

abstract：:The ongoing pandemic of a new human coronavirus, SARS-CoV-2, has generated enormous global concern. We and others in China were involved in the initial genome sequencing of the virus. Herein, we describe what genomic data reveal about the emergence SARS-CoV-2 and discuss the gaps in our understanding of its origins. ...

journal_title：Cell

authors： Zhang YZ,Holmes EC

更新日期：2020-04-16 00:00:00

abstract：:New biological tools provide new techniques to probe fundamental biological processes. Here we describe the burgeoning field of proteolysis-targeting chimeras (PROTACs), which are capable of modulating protein concentrations at a post-translational level by co-opting the ubiquitin-proteasome system. We describe the PR...

journal_title：Cell

authors： Burslem GM,Crews CM

更新日期：2020-04-02 00:00:00

abstract：:Structures of 70 unique G protein-coupled receptors (GPCRs) have been determined, with over 370 structures in total bound to different ligands and the receptors in various conformational states. Structure-based drug design has been applied to an increasing number of GPCR targets over the past decade and now a few of t...

journal_title：Cell

authors： Congreve M,de Graaf C,Swain NA,Tate CG

更新日期：2020-04-02 00:00:00

abstract：:Social impairment is frequently associated with mitochondrial dysfunction and altered neurotransmission. Although mitochondrial function is crucial for brain homeostasis, it remains unknown whether mitochondrial disruption contributes to social behavioral deficits. Here, we show that Drosophila mutants in the homolog ...

journal_title：Cell

authors： Kanellopoulos AK,Mariano V,Spinazzi M,Woo YJ,McLean C,Pech U,Li KW,Armstrong JD,Giangrande A,Callaerts P,Smit AB,Abrahams BS,Fiala A,Achsel T,Bagni C

更新日期：2020-03-19 00:00:00

abstract：:Understanding molecular mechanisms that dictate B cell diversity is important for targeting B cells as anti-cancer treatment. Through the single-cell dissection of B cell heterogeneity in longitudinal samples of patients with breast cancer before and after neoadjuvant chemotherapy, we revealed that an ICOSL+ B cell su...

journal_title：Cell

authors： Lu Y,Zhao Q,Liao JY,Song E,Xia Q,Pan J,Li Y,Li J,Zhou B,Ye Y,Di C,Yu S,Zeng Y,Su S

更新日期：2020-03-19 00:00:00

abstract：:A safe and controlled manipulation of endocytosis in vivo may have disruptive therapeutic potential. Here, we demonstrate that the anti-emetic/anti-psychotic prochlorperazine can be repurposed to reversibly inhibit the in vivo endocytosis of membrane proteins targeted by therapeutic monoclonal antibodies, as directly ...

journal_title：Cell

authors： Chew HY,De Lima PO,Gonzalez Cruz JL,Banushi B,Echejoh G,Hu L,Joseph SR,Lum B,Rae J,O'Donnell JS,Merida de Long L,Okano S,King B,Barry R,Moi D,Mazzieri R,Thomas R,Souza-Fonseca-Guimaraes F,Foote M,McCluskey A,Robin

更新日期：2020-03-05 00:00:00

abstract：:Drugs selectively targeting CB2 hold promise for treating neurodegenerative disorders, inflammation, and pain while avoiding psychotropic side effects mediated by CB1. The mechanisms underlying CB2 activation and signaling are poorly understood but critical for drug design. Here we report the cryo-EM structure of the ...

journal_title：Cell

authors： Xing C,Zhuang Y,Xu TH,Feng Z,Zhou XE,Chen M,Wang L,Meng X,Xue Y,Wang J,Liu H,McGuire TF,Zhao G,Melcher K,Zhang C,Xu HE,Xie XQ

更新日期：2020-02-20 00:00:00

abstract：:Immune responses in diverse tissue sites are critical for protective immunity and homeostasis. Here, we investigate how tissue localization regulates the development and function of human natural killer (NK) cells, innate lymphocytes important for anti-viral and tumor immunity. Integrating high-dimensional analysis of...

journal_title：Cell

authors： Dogra P,Rancan C,Ma W,Toth M,Senda T,Carpenter DJ,Kubota M,Matsumoto R,Thapa P,Szabo PA,Li Poon MM,Li J,Arakawa-Hoyt J,Shen Y,Fong L,Lanier LL,Farber DL

更新日期：2020-02-20 00:00:00

abstract：:Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network capable of predicting molecules with antibacterial activity. We performed predictions on multiple chemical libraries and discovered a molecule fr...

journal_title：Cell

authors： Stokes JM,Yang K,Swanson K,Jin W,Cubillos-Ruiz A,Donghia NM,MacNair CR,French S,Carfrae LA,Bloom-Ackermann Z,Tran VM,Chiappino-Pepe A,Badran AH,Andrews IW,Chory EJ,Church GM,Brown ED,Jaakkola TS,Barzilay R,Collins J

更新日期：2020-02-20 00:00:00

abstract：:Cortical layer 1 (L1) interneurons have been proposed as a hub for attentional modulation of underlying cortex, but the transformations that this circuit implements are not known. We combined genetically targeted voltage imaging with optogenetic activation and silencing to study the mechanisms underlying sensory proce...

journal_title：Cell

authors： Fan LZ,Kheifets S,Böhm UL,Wu H,Piatkevich KD,Xie ME,Parot V,Ha Y,Evans KE,Boyden ES,Takesian AE,Cohen AE

更新日期：2020-02-06 00:00:00

abstract：:Microbes that cause persistent infections (e.g., herpes viruses) do so by switching from fast-growing lytic states to slow-growing latent states. Waldman et al. have identified a single transcription factor that governs the switch between the lytic and latent forms of Toxoplasma gondii, a parasite that causes a persis...

journal_title：Cell

authors： Kochanowsky JA,Koshy AA

更新日期：2020-01-23 00:00:00

abstract：:Enteric-associated neurons (EANs) are closely associated with immune cells and continuously monitor and modulate homeostatic intestinal functions, including motility and nutrient sensing. Bidirectional interactions between neuronal and immune cells are altered during disease processes such as neurodegeneration or irri...

journal_title：Cell

authors： Matheis F,Muller PA,Graves CL,Gabanyi I,Kerner ZJ,Costa-Borges D,Ahrends T,Rosenstiel P,Mucida D

更新日期：2020-01-09 00:00:00

abstract：:Erythropoietin (EPO) production in the kidney is regulated by the oxygen-sensing transcription factor HIF-1α, which is degraded under normoxic conditions by HIF-prolyl hydroxylase (HIF-PHD). Inhibition of HIF-PHD by roxadustat leads to increased EPO production, better iron absorption, and amelioration of anemia in chr...

journal_title：Cell

authors： Voit RA,Sankaran VG

更新日期：2020-01-09 00:00:00

abstract：:During cell division, newly replicated DNA is actively segregated to the daughter cells. In most bacteria, this process involves the DNA-binding protein ParB, which condenses the centromeric regions of sister DNA molecules into kinetochore-like structures that recruit the DNA partition ATPase ParA and the prokaroytic ...

journal_title：Cell

authors： Osorio-Valeriano M,Altegoer F,Steinchen W,Urban S,Liu Y,Bange G,Thanbichler M

更新日期：2019-12-12 00:00:00

abstract：:Cells are protected from endoplasmic reticulum stress through the unfolded protein response (UPR). In this issue of Cell, Schinzel, Higuchi-Sanabria, Shalem et al., identify a mechanism that helps cells cope with ER stress but is independent of canonical UPR activation, instead involving the extracellular matrix hyalu...

journal_title：Cell

authors： Koopman M,Hetz C,Nollen EAA

更新日期：2019-11-27 00:00:00

abstract：:The increasing proportion of variance in human complex traits explained by polygenic scores, along with progress in preimplantation genetic diagnosis, suggests the possibility of screening embryos for traits such as height or cognitive ability. However, the expected outcomes of embryo screening are unclear, which unde...

journal_title：Cell

authors： Karavani E,Zuk O,Zeevi D,Barzilai N,Stefanis NC,Hatzimanolis A,Smyrnis N,Avramopoulos D,Kruglyak L,Atzmon G,Lam M,Lencz T,Carmi S

更新日期：2019-11-27 00:00:00

abstract：:Ocean microbial communities strongly influence the biogeochemistry, food webs, and climate of our planet. Despite recent advances in understanding their taxonomic and genomic compositions, little is known about how their transcriptomes vary globally. Here, we present a dataset of 187 metatranscriptomes and 370 metagen...

journal_title：Cell

authors： Salazar G,Paoli L,Alberti A,Huerta-Cepas J,Ruscheweyh HJ,Cuenca M,Field CM,Coelho LP,Cruaud C,Engelen S,Gregory AC,Labadie K,Marec C,Pelletier E,Royo-Llonch M,Roux S,Sánchez P,Uehara H,Zayed AA,Zeller G,Carmichael

更新日期：2019-11-14 00:00:00

abstract：:Cell-cell junctions respond to mechanical forces by changing their organization and function. To gain insight into the mechanochemical basis underlying junction mechanosensitivity, we analyzed tight junction (TJ) formation between the enveloping cell layer (EVL) and the yolk syncytial layer (YSL) in the gastrulating z...

journal_title：Cell

authors： Schwayer C,Shamipour S,Pranjic-Ferscha K,Schauer A,Balda M,Tada M,Matter K,Heisenberg CP

更新日期：2019-10-31 00:00:00

abstract：:Antisense Piwi-interacting RNAs (piRNAs) guide silencing of established transposons during germline development, and sense piRNAs drive ping-pong amplification of the antisense pool, but how the germline responds to genome invasion is not understood. The KoRV-A gammaretrovirus infects the soma and germline and is swee...

journal_title：Cell

authors： Yu T,Koppetsch BS,Pagliarani S,Johnston S,Silverstein NJ,Luban J,Chappell K,Weng Z,Theurkauf WE

更新日期：2019-10-17 00:00:00

abstract：:A single mouse blastomere from an embryo until the 8-cell stage can generate an entire blastocyst. Whether laboratory-cultured cells retain a similar generative capacity remains unknown. Starting from a single stem cell type, extended pluripotent stem (EPS) cells, we established a 3D differentiation system that enable...

journal_title：Cell

authors： Li R,Zhong C,Yu Y,Liu H,Sakurai M,Yu L,Min Z,Shi L,Wei Y,Takahashi Y,Liao HK,Qiao J,Deng H,Nuñez-Delicado E,Rodriguez Esteban C,Wu J,Izpisua Belmonte JC

更新日期：2019-10-17 00:00:00

abstract：:Pulmonary neuroendocrine (NE) cells are neurosensory cells sparsely distributed throughout the bronchial epithelium, many in innervated clusters of 20-30 cells. Following lung injury, NE cells proliferate and generate other cell types to promote epithelial repair. Here, we show that only rare NE cells, typically 2-4 p...

journal_title：Cell

authors： Ouadah Y,Rojas ER,Riordan DP,Capostagno S,Kuo CS,Krasnow MA

更新日期：2019-10-03 00:00:00

abstract：:Development of microbiota-directed foods (MDFs) that selectively increase the abundance of beneficial human gut microbes, and their expressed functions, requires knowledge of both the bioactive components of MDFs and the mechanisms underlying microbe-microbe interactions. Here, gnotobiotic mice were colonized with a d...

journal_title：Cell

authors： Patnode ML,Beller ZW,Han ND,Cheng J,Peters SL,Terrapon N,Henrissat B,Le Gall S,Saulnier L,Hayashi DK,Meynier A,Vinoy S,Giannone RJ,Hettich RL,Gordon JI

更新日期：2019-09-19 00:00:00

abstract：:During neural tube closure and spinal cord development, many cells die in both the central and peripheral nervous systems (CNS and PNS, respectively). However, myeloid-derived professional phagocytes have not yet colonized the trunk region during early neurogenesis. How apoptotic cells are removed from this region dur...

journal_title：Cell

authors： Zhu Y,Crowley SC,Latimer AJ,Lewis GM,Nash R,Kucenas S

更新日期：2019-09-19 00:00:00

abstract：:Although clonal neo-antigen burden is associated with improved response to immune therapy, the functional basis for this remains unclear. Here we study this question in a novel controlled mouse melanoma model that enables us to explore the effects of intra-tumor heterogeneity (ITH) on tumor aggressiveness and immunity...

journal_title：Cell

authors： Wolf Y,Bartok O,Patkar S,Eli GB,Cohen S,Litchfield K,Levy R,Jiménez-Sánchez A,Trabish S,Lee JS,Karathia H,Barnea E,Day CP,Cinnamon E,Stein I,Solomon A,Bitton L,Pérez-Guijarro E,Dubovik T,Shen-Orr SS,Miller ML,Me

更新日期：2019-09-19 00:00:00

abstract：:This year's Lasker-Bloomberg Public Service Award goes to GAVI, the Vaccine Alliance, for providing sustained access to childhood vaccines around the globe, saving millions of lives, and highlighting the power of immunization to prevent disease. ...

journal_title：Cell

authors： Zerhouni E

更新日期：2019-09-19 00:00:00

abstract：:Clinical benefits of cytokine blockade in ileal Crohn's disease (iCD) are limited to a subset of patients. Here, we applied single-cell technologies to iCD lesions to address whether cellular heterogeneity contributes to treatment resistance. We found that a subset of patients expressed a unique cellular module in inf...

journal_title：Cell

authors： Martin JC,Chang C,Boschetti G,Ungaro R,Giri M,Grout JA,Gettler K,Chuang LS,Nayar S,Greenstein AJ,Dubinsky M,Walker L,Leader A,Fine JS,Whitehurst CE,Mbow ML,Kugathasan S,Denson LA,Hyams JS,Friedman JR,Desai PT,Ko

更新日期：2019-09-05 00:00:00

abstract：:Infectious disease is both a major force of selection in nature and a prime cause of yield loss in agriculture. In plants, disease resistance is often conferred by nucleotide-binding leucine-rich repeat (NLR) proteins, intracellular immune receptors that recognize pathogen proteins and their effects on the host. Consi...

journal_title：Cell

authors： Van de Weyer AL,Monteiro F,Furzer OJ,Nishimura MT,Cevik V,Witek K,Jones JDG,Dangl JL,Weigel D,Bemm F

更新日期：2019-08-22 00:00:00

abstract：:The Zika epidemic in the Americas has challenged surveillance and control. As the epidemic appears to be waning, it is unclear whether transmission is still ongoing, which is exacerbated by discrepancies in reporting. To uncover locations with lingering outbreaks, we investigated travel-associated Zika cases to identi...

journal_title：Cell

authors： Grubaugh ND,Saraf S,Gangavarapu K,Watts A,Tan AL,Oidtman RJ,Ladner JT,Oliveira G,Matteson NL,Kraemer MUG,Vogels CBF,Hentoff A,Bhatia D,Stanek D,Scott B,Landis V,Stryker I,Cone MR,Kopp EW 4th,Cannons AC,Heberlein-L

更新日期：2019-08-22 00:00:00

abstract：:Metabolic conditions affect the developmental tempo of animals. Developmental gene regulatory networks (GRNs) must therefore synchronize their dynamics with a variable timescale. We find that layered repression of genes couples GRN output with variable metabolism. When repressors of transcription or mRNA and protein s...

journal_title：Cell

authors： Cassidy JJ,Bernasek SM,Bakker R,Giri R,Peláez N,Eder B,Bobrowska A,Bagheri N,Nunes Amaral LA,Carthew RW

更新日期：2019-08-08 00:00:00

abstract：:We performed a comprehensive assessment of rare inherited variation in autism spectrum disorder (ASD) by analyzing whole-genome sequences of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD risk, including 24 passing genome-wide Bonferroni correction and 16 new ASD risk gen...

journal_title：Cell

authors： Ruzzo EK,Pérez-Cano L,Jung JY,Wang LK,Kashef-Haghighi D,Hartl C,Singh C,Xu J,Hoekstra JN,Leventhal O,Leppä VM,Gandal MJ,Paskov K,Stockham N,Polioudakis D,Lowe JK,Prober DA,Geschwind DH,Wall DP

更新日期：2019-08-08 00:00:00

abstract：:Nociceptin and its receptor are widely distributed throughout the brain in regions associated with reward behavior, yet how and when they act is unknown. Here, we dissected the role of a nociceptin peptide circuit in reward seeking. We generated a prepronociceptin (Pnoc)-Cre mouse line that revealed a unique subpopula...

journal_title：Cell

authors： Parker KE,Pedersen CE,Gomez AM,Spangler SM,Walicki MC,Feng SY,Stewart SL,Otis JM,Al-Hasani R,McCall JG,Sakers K,Bhatti DL,Copits BA,Gereau RW,Jhou T,Kash TJ,Dougherty JD,Stuber GD,Bruchas MR

更新日期：2019-07-25 00:00:00

abstract：:Chemotherapy is designed to induce cell death. However, at non-lethal doses, cancer cells can choose to remain proliferative or become senescent. The slow development of senescence makes studying this decision challenging. Here, by analyzing single-cell p21 dynamics before, during, and days after drug treatment, we li...

journal_title：Cell

authors： Hsu CH,Altschuler SJ,Wu LF

更新日期：2019-07-11 00:00:00

abstract：:Pathogenic and other cytoplasmic DNAs activate the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway to induce inflammation via transcriptional activation by IRF3 and nuclear factor κB (NF-κB), but the functional consequences of exposing cGAS to chromosomes upon mitotic nuclear envelope bre...

journal_title：Cell

authors： Zierhut C,Yamaguchi N,Paredes M,Luo JD,Carroll T,Funabiki H

更新日期：2019-07-11 00:00:00

abstract：:Social interactions occur between multiple individuals, but what is the detailed relationship between the neural dynamics across their brains? To address this question across timescales and levels of neural activity, we used wireless electrophysiology to simultaneously record from pairs of bats engaged in a wide range...

journal_title：Cell

authors： Zhang W,Yartsev MM

更新日期：2019-07-11 00:00:00

abstract：:Neurons in cortical circuits are often coactivated as ensembles, yet it is unclear whether ensembles play a functional role in behavior. Some ensemble neurons have pattern completion properties, triggering the entire ensemble when activated. Using two-photon holographic optogenetics in mouse primary visual cortex, we ...

journal_title：Cell

authors： Carrillo-Reid L,Han S,Yang W,Akrouh A,Yuste R

更新日期：2019-07-11 00:00:00

abstract：:Viral infection causes the host to activate an antiviral response that, in part, is dependent on mitochondrial antiviral signaling protein (MAVS) to stimulate type I interferons. Zhang et al. (2019) demonstrate that glucose-generated lactate interacts with MAVS to suppress type I interferons. This study links glucose ...

journal_title：Cell

authors： Stoolman JS,Chandel NS

更新日期：2019-06-27 00:00:00

abstract：:It is unknown whether the activity of the nervous system can be inherited. In Caenorhabditis elegans nematodes, parental responses can transmit heritable small RNAs that regulate gene expression transgenerationally. In this study, we show that a neuronal process can impact the next generations. Neurons-specific synthe...

journal_title：Cell

authors： Posner R,Toker IA,Antonova O,Star E,Anava S,Azmon E,Hendricks M,Bracha S,Gingold H,Rechavi O

更新日期：2019-06-13 00:00:00